Author

He-Qian Jiang

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Review Oct 2026

Pathogenesis and therapeutic targets of neuroinflammation in Alzheimer's disease mediated by microglia lysosomal dysfunction.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by two core pathological features: senile plaques formed by amyloid-β protein (Aβ) deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. In recent years, neuroinflammation has been recognized as a key driver...

Ming-Sheng Zi, Qiu-Yan Ye, Ming-Yuan Yao et al. · Journal of Alzheimer's Disea... · 0 citations

Review Aug 2026

Pyroptosis in Alzheimer's disease: Mechanisms and neuroinflammatory networks.

Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.

Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al. · Molecular and cellular neuro... · 0 citations