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Advances in the study of the role of bone immunity in physiological and pathological processes related to bone metabolism.
The net skeletal effect of the immune system is determined by the balance of interacting cell types, cytokine networks, and signaling pathways, and systematic evaluation of combination strategies pairing immunomodulators with anti-resorptive, anabolic agents, or senolytics.
Aging of Mesenchymal Stem Cells in Bone Aging: Mechanisms, Impact, and Therapeutic Perspectives.
Aging of the skeleton is a hallmark of organismal decline and underlies prevalent age-related disorders such as osteoporosis and osteoarthritis. Bone marrow-derived mesenchymal stem cells (BMSCs), the primary source of osteoblasts, undergo profound functional deterioration during senescence, leading to an imbalance bet...