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Author

He-Yang Zhang

2 papers indexed here

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Open access Aug 2026

Pan-cancer Evaluation of the Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker Across Six Major Solid Tumors

Background/Aim: Systemic inflammation is increasingly recognized as a key hallmark of cancer progression and an important determinant of patient outcomes, reflecting the balance between tumor-promoting inflammatory activity and anti-tumor immune competence. Using routinely available peripheral blood counts, we evaluate...

Gui-Lan Cai, Xiao Zhang, He-Yang Zhang et al. · 0 citations
Open access Sep 2026

Glucose-induced histone lactylation confers metformin resistance in colorectal cancer stem cells

Cancer stem cells (CSCs) can adapt their metabolism, which limits the effectiveness of therapies targeting metabolic pathways. Here we show that high glucose conditions promote metformin resistance in CD133⁺ colorectal CSCs by driving a switch from glucose dependence to lipid use. Mechanistically, metformin increases...

Xiangrui Li, Li Deng, Tian-Ge Zhang et al. · 0 citations

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