Heather H. Sestili

An Epigenetic Signature of Vulnerable Neurons is Under Selective Pressure Associated with Longevity Across Placental Mammals

Age is the primary risk factor for neurodegenerative diseases, which are characterized by cell-type-specific vulnerability 1. Yet brain-aging mechanisms remain unclear given the complex, interacting age-associated pathways across diverse neural cell types. Here, we dissect cell type- cell state-specific aging gene regu...