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Author

Heather N. Allen

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Open access Sep 2026

Peripheral NaV1.7 modulation reveals divergent peripheral and central adaptations in persistent trigeminal pain

Trigeminal pain produces persistent facial hypersensitivity that is difficult to treat. Ion channels contribute to the pathology of trigeminal pain, but the consequences of their modulation remain poorly understood. We previously demonstrated that voltage-gated sodium channel Nav1.7 is a therapeutic target that can be...

Heather N. Allen, Naomi K. Grabus, Rajesh Khanna · 0 citations
Open access Sep 2026

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

Pain is among the most prevalent and disabling nonmotor symptoms of Parkinson’s disease (PD), yet its mechanisms remain poorly defined and effective treatments are limited. Safinamide is one of the few drugs reported to improve pain in PD, but the mechanism underlying this effect is unknown. Here, we show that nigrostr...

Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al. · 1 citation

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