Jul 2026
Adolescent drinking causes a loss of aspartoacylase-expressing oligodendrocytes and hypomyelination of anterior cingulate and corpus callosum axons in male mice, but not females.
The findings advance the mechanistic understanding of myelin deficits after alcohol, identifying late-stage oligodendroglial development and ASPA as possible targets for therapeutic intervention in the treatment of alcohol use disorder and demyelinating diseases.
Saïd Akli, A. Flores-Bonilla, S. Nouduri et al.
· Neuroscience · 0 citations