Author

Heba M. Hesham

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Open access Sep 2026

Design, synthesis, structure-activity relationship and in-silico studies of novel pyrazolo[1,5-a]pyrimidine derivatives as selective COX-2 inhibitors with promising anti-inflammatory activity and safety profile.

Selective COX-2 inhibitors offer effective anti-inflammatory therapy with minimized gastrointestinal side effects, yet developing novel scaffolds with superior safety profiles remains critical. In this study, a novel series of pyrazolo[1,5-a]pyrimidine derivatives (7a-b, 8a-j, 9a-b, and 12a-e) was designed using ligand...

Alaa Omar Mohamed Helmy, A. Taher, Eman Z. El Razaz et al. · Bioorganic chemistry (Print) · 0 citations

Aug 2026

Design and synthesis of novel thiazolotriazole-sulfonamide hybrids tackling antimicrobial resistance: mechanistic insights into efflux pump inhibitor, gene downregulation, and machine-aided results.

The escalating global threat of antimicrobial resistance necessitates innovative therapeutic strategies. In this study, a novel series of thiazolotriazole-sulfonamide hybrids was designed using a molecular hybridization strategy. Computational potency was predicted via pharmacophore modelling, identifying biologically...

Hossam H. Elsayed, Eman Z. Elrazaz, Maiy Y Jaballah et al. · Bioorganic chemistry (Print) · 0 citations