Open access
Jul 2026
A single-domain antibody targets aggregation-prone region of α-synuclein to reduce synucleinopathy, rescue neurodegeneration and improve function
The therapeutic potential of five anti-α-syn single-domain antibodies to clear pathological α-syn in mouse neuronal culture is evaluated and their in vivo efficacy is demonstrated in a Drosophila model of synucleinopathy.
Pragati, E. E. Congdon, Yixiang Jiang et al.
· bioRxiv · 0 citations