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Heejung Ha

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Open access Sep 2026

Osteoprotegerin lowers type 2 diabetes risk: insights from drug-target Mendelian randomization and mediation analysis

Observational evidence suggests that denosumab, which acts through a mechanism partially analogous to that of the endogenous protein osteoprotegerin (OPG), may be associated with a lower risk of type 2 diabetes (T2D). This raises the possibility that modulation of the OPG pathway may influence diabetes risk. We a...

Heejung Ha, Wooin Lee, Yi-Jin An et al. · 0 citations

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