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Author

Hélder A. Santos

2 papers indexed here

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Open access Sep 2026

From Coordination Chemistry to Immune Modulation: Rational Design of Next‐Generation Mn 2+ ‐Based Immunomodulators

Mn 2+ has emerged as a potent immunostimulatory modulator capable of activating cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) and other innate immune signaling pathways. Consequently, Mn 2+ induces type I interferon responses, and promotes robust antitumor and antiviral immunity. Recent...

Xin Zhang, Hélder A. Santos, Bing Xia · 0 citations
Open access Aug 2026

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Extracellular vesicles (EVs) from immune cells represent a novel drug delivery system with inherent anti‐tumor properties. To remodel the immunosuppressive tumor microenvironment and mediate multimodal therapy, we produced neutrophil nanovesicles at high yield and loaded them with drug (doxorubicin, DOX), near‐infr...

Jia-Hui Zhang, Cheng Ji, Xin-Jian Fang et al. · 0 citations

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