Author

Helena Zambrano

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Open access Aug 2026

Selective impairment of long-term depression in accumbal D1R+ MSNs involves calcium-permeable AMPARs in early Alzheimer's disease.

A pre-plaque, cell-type-specific synaptic phenotype in male APP/PS1 mice is defined in which impaired mGluR1/5-dependent plasticity and persistent CP-AMPAR signaling in D1R+ MSNs coincide with selective reward-related alterations.

Nicolás Riffo-Lepe, Juliana González-Sanmiguel, Isaías Meza et al. · Neurobiology of Disease · 0 citations