Author

Helga Othmen

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Open access Sep 2026

Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains

Mutations in the transcription factor LMX1B have been identified as the cause of the autosomal-dominant disease nail-patella syndrome. It manifests in small or absent patellae and dysplastic or missing toe- and fingernails, but the prognosis of the patients is determined by the development of renal symptoms due to dysf...

Joshua Hermens, Lisa Lucke, O. Pieles et al. · Nature Communications · 0 citations

Open access Aug 2026

GRAF1-dependent endocytotic processes and the Golgi apparatus contribute to previously unrecognized intermediate stages of early ciliogenesis

A three-dimensional ultrastructural analysis reveals previously unrecognized intermediate stages in the formation of primary cilia and identifies the endocytotic protein GRAF1 as being essential during the early stages of ciliogenesis and for the delivery of plasma membrane-derived material to the developing ciliary me...

Kerstin N. Schmidt, Korbinian Buerger, Olga Maier et al. · Nature Communications · 0 citations