Heng-Hai Nie

Characterization of Pulmonary Tropism, Expression Kinetics and Safety of the Novel Adeno-Associated Virus-LungM3 Vector.

This study investigated the lung-targeting characteristics, dose- and time-dependent effects, and safety of a novel engineered adeno-associated virus (AAV) vector, AAV-LungM3. In vitro, mouse primary lung organoids were transduced with AAV-LungM3 at doses of 103, 104, and 105 vector genomes (vg)/cell, and transduction...