Author

Heng Liu

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Open access Sep 2026

Structure based discovery of antipsychotic-like TAAR1 agonists

Schizophrenia is a severe mental illness whose current treatments primarily target dopamine and serotonin receptors. These drugs often cause side effects and vary in effectiveness across patients. The trace amine-associated receptor 1 (TAAR1), which modulates monoamine signaling, has emerged as a promising alternativ...

Si-Jie Huang, Heng Liu, Yu-Jin Wu et al. · Nature Communications · 0 citations

Open access Jul 2026

Molecular principles for graded activation of dopamine D1 receptor

G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorly understood. Here, we define the molecular mechanism underlying graded activation of the dopamine D1 receptor (D1R), a major therapeutic target for neuropsychiatric diso...

Xinyue Zhang, Yu Zheng, Heng Liu et al. · bioRxiv · 0 citations