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Aug 2026

Prdx2 suppresses the erythroid differentiation by modulating the ROS-JNK1 signaling axis.

Erythroleukemia is a rare but aggressive subtype of acute myeloid leukemia with a poor prognosis and limited therapeutic options. Impaired erythroid differentiation is a hallmark of this disease, yet the underlying molecular mechanisms remain incompletely understood. Peroxiredoxin 2 (PRDX2), a key antioxidant enzyme in...

Dan Xie, Mingyue Yang, Sha Cheng et al. · 0 citations
Open access Jul 2026

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms

KZL-064 is identified, a 2-trifluoromethyl-4-aminoquinazoline derivative, which markedly inhibits HCC cell proliferation, migration, and invasion, induces apoptosis and G2/M arrest, and oral administration achieves tumor suppression comparable to that of sorafenib without significant toxicity.

Shi-Mei Wang, Xudong Cui, Gang Yu et al. · 0 citations

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