Author

Heng Tang

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Open access Sep 2026

TET1 loss promotes malignant phenotypes in HeLa cells and is associated with altered PTEN–PI3K/AKT/mTOR signaling

To investigate the biological significance of ten–eleven translocation 1 (TET1) in cervical cancer and its association with PTEN–PI3K/AKT/mTOR signaling. Publicly available bulk and single-cell transcriptomic datasets were analyzed, with histology-restricted analyses focused on cervical squamous cell carcino...

Yan Liu, Lu-Jia Liu, Lu-Sheng Wang et al. · Frontiers in Oncology · 0 citations

Open access Aug 2026

Quercetin protects HTR-8/SVneo human trophoblast cells against oxidative stress injury via activating EGFR/PI3K/AKT-NRF2/HO-1 signaling axis

Adverse pregnancy outcomes represented by recurrent spontaneous abortion remain a global clinical problem, with excessive oxidative stress-induced trophoblast dysfunction as its well-recognized core pathological mechanism. Quercetin is a natural flavonoid with strong antioxidant and cytoprotective effects, but its prot...

Lu-Jia Liu, Zhixian Ding, Yina Wu et al. · Frontiers in Pharmacology · 0 citations

Aug 2026

A halotolerant marine β-glucosidase from Celeribacter halophilus for efficient bioconversion of soybean isoflavone glycosides to bioactive aglycones.

High catalytic efficiency in hydrolyzing glycosidic bonds and substantial increases in the yields of bioactive daidzein and genistein are highlighted, highlighting ChaBGL's significant potential for diverse industrial applications, particularly in the nutritional, veterinary, and pharmaceutical sectors.

Fei Chang, Yi-Le Wang, Jian-Ping Ou et al. · Enzyme and Microbial Technol... · 0 citations