Author

Heng-Xiang Liu

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Review Open access Sep 2026

Beyond Exosomes: Biological Properties, Isolation Challenges, and Functional Redefinition of Non-Vesicular Extracellular Nanoparticles (NVEPs)

Extracellular vesicles (EVs) have dominated research on intercellular communication for decades. However, the discovery of exomeres in 2018 revealed that conventional exosome preparations contain large quantities of long-overlooked non-membranous nanoparticles. Additional non-vesicular extracellular nanoparticles (NVEP...

Heng-Xiang Liu, Zi-Shuai Chen, Hai He et al. · Biomolecules · 0 citations

Review Open access Sep 2026

Biomaterial strategies for precision regeneration of the tooth extraction socket: integrating site phenotype, pathological microenvironment, and healing sequence

Alveolar ridge remodeling after tooth extraction is not merely a process of bone defect repair; rather, it is jointly regulated by the anatomical phenotype, pathological microenvironment, surgical procedures, subsequent restorative objectives, and temporal healing sequence of the socket. Existing studies on extraction...

Hai He, Zi-Shuai Chen, Heng-Xiang Liu et al. · Frontiers in Bioengineering... · 0 citations

Jul 2026

DT-Guard: Intent-Driven Reasoning-Active Training for Reasoning-Free LLM Safety Guardrail

DT-Guard is presented, a content safety guardrail model based on a Reasoning-Active Training, Reasoning-Free Inference paradigm, which demonstrates that reasoning supervision can be effectively internalized into low-latency safety discrimination.

Heng-Xiang Liu, Changtao Miao, Xinjie Yang et al. · arXiv.org · 0 citations