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Open access Sep 2026

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Spinal cord injury (SCI) often causes permanent neurological deficits due to limited neuron regeneration and glial scar formation. Stem cell therapy is promising, but transplanted stem cells often differentiate into astrocytes rather than neurons under inflammatory conditions. To address this, a nuclei‐targeting, his...

Heng Zhou, Qiang Qin, Xi-Qin Li et al. · 0 citations
Open access Sep 2026

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure.

Cardiac hypertrophy is a major pathological response to cardiovascular stress and a critical contributor to heart failure (HF). Gentiopicroside (GPS), a naturally occurring iridoid glycoside derived from Gentiana scabra, exhibits anti-inflammatory, antioxidant, and anti-fibrotic properties. However, its role and molecu...

Ming-Zhen Cao, Da Ke, Jian Ni et al. · 0 citations

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