Open access
Jul 2026
Targeting DNMT1 augments anti-tumor CD8⁺ T cell function
DNMT1 targeting is established as a promising strategy to counteract CD8⁺ T cell exhaustion and potentiate ICI efficacy and enhances the effector function of melanoma patient-derived tumor infiltrating lymphocytes after prolonged ex vivo expansion.
M. Deshmukh, Danielle K. Sohai, Kamal Obbad et al.
· bioRxiv · 0 citations