Hichem Sadrik Kettouche

Diastereoselective Mannich Synthesis of β-Amino Ketones Catalyzed by a ZrO(L-Proline)2 Hybrid System

A three-component Mannich reaction catalyzed by a ZrO(L-proline)₂ hybrid catalyst was investigated for the synthesis of β-amino ketones under mild conditions. Aromatic aldehydes, anilines, and cyclohexanone were reacted in the presence of the catalyst to afford the corresponding products in moderate yields (32-68%)...