Open access
Oct 2026
Environmental enrichment differentially suppresses anxiety-related behaviors, reduces passive avoidance learning, and upregulates hippocampal brain-derived neurotrophic factor expression in high- and low-avoidance Hatano rats.
Anxiety disorder risk is influenced by both adverse environmental factors and genetic background. We previously described high-avoidance animal (HAA) and low-avoidance animal (LAA) strains of male Hatano rats that may provide robust models for assessing interactions between genetic background and environment driving an...
Tatsuhiro Akaishi, Airi Nakayama, Hasuka Okawa et al.
· Physiology and Behavior · 0 citations