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Hideyuki Okuma

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Open access Oct 2026

Baseline monocyte SGLT2 mRNA expression and changes in the fibrosis-4 index after luseogliflozin treatment in participants with type 2 diabetes and MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in type 2 diabetes. We investigated the association between monocyte mRNA expression of sodium-glucose cotransporter 2 (SGLT2), the molecular target of luseogliflozin, and changes in the fibrosis-4 (FIB-4) index during treatment with this agent....

Hideyuki Okuma · 0 citations
Open access Aug 2026

Serum‐derived microribonucleic acids as potential novel biomarkers for slowly progressive type 1 diabetes mellitus

ABSTRACT Objectives We aimed to identify microribonucleic acids (miRNAs) that could serve as biomarkers for slowly progressive type 1 diabetes mellitus (SPIDDM). Materials and Methods We conducted a retrospective study of adult patients with SPIDDM who fulfilled the criteria for SPIDDM (definite) (n = 60), type 2 diabe...

Hideyuki Okuma, Takahiro Tsutsumi, Masashi Ichijo et al. · 0 citations

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