Natural product-derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic-ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour. Among stress-activated ion channels implicated in these c...