Author

Hirofumi Jono

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Open access Aug 2026

Comparison of Two Population Pharmacokinetic Models for Predictive Performance in Vancomycin Therapeutic Drug Monitoring.

Introduction Accurate model-based prediction of vancomycin concentration is essential for therapeutic drug monitoring (TDM); however, the practical criteria for selecting population pharmacokinetic (PopPK) models remain unclear. We compared the predictive performances of the Japanese Oda and Yamamoto PopPK models. Me...

Saki Harada, Kazutaka Oda, Shoji Kondo et al. · Hospital Pharmacy · 0 citations

Sep 2026

Nonlinear Pharmacokinetic Modeling to Support Clinical Management of Severe Caffeine Intoxication: A Short Communication.

BACKGROUND Severe caffeine intoxication may result in life-threatening complications and prolonged toxicity due to its saturable metabolism. However, quantitative information regarding the duration of caffeine exposure is limited. Whether nonlinear pharmacokinetic modeling could support the prediction of toxic exposure...

Kazutaka Oda, Maiko Hori, Fumihiro Nishimura et al. · Therapeutic Drug Monitoring · 0 citations

Aug 2026

Development and validation of machine learning model for selecting the optimal population pharmacokinetic model for vancomycin.

INTRODUCTION Therapeutic drug monitoring (TDM) of vancomycin is recommended based on the area under the concentration-time curve (AUC). The Practical Antimicrobial TDM (PAT) software incorporates two population pharmacokinetic (popPK) models developed by Oda et al. and Yasuhara et al.; however, no objective criteria fo...

H. Akamatsu, Yukinobu Kodama, Ayaka Terai et al. · Journal of Infection and Che... · 0 citations