Hirokazu Kimura

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer

The incidence of colorectal cancer (CRC) has risen in recent decades, with a disproportionate increase observed among younger individuals in Japan and other countries. The etiological contribution of the gut microbiota to CRC pathogenesis is recognized, yet the mechanisms involved remain to be fully clarified. Here we...