Hiroki Kameda

Boron trifluoride-catalyzed Diels-Alder reaction of α,β-unsaturated iminoindoles for the construction of 2-imino-3-spiroindoles.

Despite the relevance of 2-imino-3-spiroindoles, particularly in medicinal chemistry, their synthesis still relies on highly reactive coupling partners. Herein, a novel approach to 2-imino-3-spiroindoles, involving the BF3-catalyzed Diels-Alder reaction of α,β-unsaturated iminoindoles with substituted dienes, is presen...