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Author

Hiroki Oguri

2 papers indexed here

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Oct 2026

Cryo-EM Structure of a Monomeric Safracin B Nonribosomal Peptide Synthetase Enabled by an MbtH-like Protein and Covalent Probe Trapping

Nonribosomal peptide synthetases (NRPSs) assemble structurally complex natural products but remain challenging targets for high-resolution structural analysis because of their conformational heterogeneity and dynamic catalytic cycles. SacC/SfmC is an unusual single-module NRPS that diverges from canonical peptide-for...

Naoto Haraguchi, Kanami Takahashi, Kana Matsuda et al. · 0 citations
Open access Sep 2026

Integrated Scaffold Redesign and iPSC-Based Screening Reveal Potent Antifibrotic Artemisinin Analogs in Systemic Sclerosis Models

Fibrotic diseases remain among the most intractable human disorders, largely due to the absence of therapies capable of directly modulating the core cellular programs that drive pathological matrix deposition and tissue remodeling. To address this unmet medical need, we report an integrated, chemistry-driven discovery...

Takehiro Ishiga, T. Ikawa, Nobuto Kaneko et al. · 0 citations

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