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Hiroki Saito

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Open access Oct 2026

Mycothiazole enables structural characterization of entire ubiquinone-accessing tunnel in mitochondrial respiratory complex I

Mitochondrial NADH-ubiquinone (UQ) oxidoreductase (respiratory complex I) reduces UQ within its long tunnel-like cavity, which is coupled to triggering proton translocation at the membrane domain. Although mammalian complex I adopts distinct “open” and “closed” conformations, the architecture of the UQ-accessing tunnel...

Shinsuke Akisada, Ryohei Otani, Takahiro Masuya et al. · 0 citations

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