Open access
Sep 2026
Polycomb establishes TAD-scale H3K27me3 mega-domains to safeguard neuronal identity
These findings reveal a previously unrecognized role for PRCs in establishing TAD-scale repressive chromatin domains during neuronal maturation, thereby safeguarding neuronal identity from external stimuli through broad silencing of alternative cell fate programs.
Natsumi Yamada, Chika Ichihara, Kazunori Hojo et al.
· bioRxiv · 0 citations