Supramolecular Hemoglobin-PEG Polymerization Equilibria as the Structural Basis for Providing Size-Controlled Polymer Particles.
Hemoglobin (Hb) can act as a dynamic supramolecular building block through the reversible dissociation of the α2β2 tetramer into αβ dimers. For this study, we designed structurally defined bicyclic monomers in which the β subunits in two Hb molecules are bridged through four-armed PEG of different molecular weights (10...