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Hirono Ito

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Open access Sep 2026

Evaluation of Histidine–Octamer-Modified Hyaluronic Acid as a Cytosolic Drug Delivery Material via CD44-Mediated Cellular Uptake and Endosomal Escape

Background: Although intracellular delivery via endocytosis is a promising strategy for drugs acting in the cytosol or nucleus, many macromolecular therapeutics remain trapped within endosomal/lysosomal compartments, limiting efficient cytosolic delivery. In this study, we designed a novel functional hyaluronic acid (H...

Tomona Yukimura, Hirono Ito, Takahiro Suzuki et al. · 0 citations

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