Author

Hironobu Hojo

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Open access Aug 2026

Mining of Novel Human DPP-IV-Targeting Tripeptides through Multicomputational Screening and In Vitro Validation for Diabetes Therapy

Inhibition of human dipeptidyl peptidase IV (hDPP-IV) is considered an effective strategy in the management of type 2 diabetes (T2D). However, the lack of high-throughput screening approaches and the high cost of experimental evaluation have limited the discovery of peptide-based hDPP-IV inhibitors. Herein, an integrat...

James V. Lavilla, F. K. Burnea, Hironobu Hojo et al. · ACS Omega · 0 citations

Open access Aug 2026

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Results suggest that posttranslational modifications of αSyn do not induce significant secondary structural changes in monomeric αSyn, suggesting that the modifications themselves do not induce significant secondary structural changes in monomeric αSyn.

Tatsuhito Matsuo, I. Suetake, Mariko Kimura et al. · Journal of Peptide Science · 0 citations