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Author

Hiroshi Abe

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Open access Sep 2026

Enhanced CRISPR-Cas3-mediated genome editing using circularized crRNAs

Summary Type I-E CRISPR-Cas3 represents a genome-editing technology in which large deletions averaging several kilobases are introduced in target regions. However, its genome-editing efficiency varies considerably across targets and cell types, making it difficult to achieve consistent results. Here, we investigated th...

Kouya Mikamo, K. Yoshimi, Naoko Abe et al. · 0 citations
Open access Jul 2026

Circular Photocaged mRNA for Light-induced Late-stage Activation of Translation.

mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent. Despite notable advances in manufacturing, stabilization and modification, its short half-life remains a major limitation. Circular RNA bears potential to solve this issue, as degradation of mRNA proceeds primarily from th...

Bayram Terzi, Greta Charlotte Dahm, Kristoffer Heintz et al. · 0 citations

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