Author

Hiroshi Harada

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Open access Aug 2026

The lariat RNA debranching enzyme DBR1 enhances HIF-1 signaling and chemoresistance at the expense of lariat RNA processing.

Severely hypoxic microenvironments that induce cell-cycle arrest and chemoresistance are frequently found within solid tumors. Since hypoxia-inducible factor 1 (HIF-1) serves as a central transcription factor for cellular adaptation to oxygen deprivation, identification of novel regulators of HIF-1 activity may provide...

Phuong Thi Lien Nguyen, Minoru Kobayashi, S. Koyasu et al. · Journal of Biological Chemis... · 0 citations

Open access Sep 2026

IDH3-dependent mitochondrial function in stromal fibroblasts suppresses malignant tumor growth.

Malignant solid tumors comprise not only cancer cells but also diverse non-cancerous stromal cells that shape the tumor microenvironment. The tricarboxylic acid (TCA) cycle has an overarching presence in providing substrates needed to drive the electron transport chain and, ultimately, ATP synthesis. However, it remain...

L. R. Koseki, Minoru Kobayashi, Mai Ito et al. · Neoplasia · 0 citations