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Author

Hiroyasu Onaka

2 papers indexed here

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Review Open access Sep 2026

Glutathione acts as an exometabolite that promotes growth recovery in fission yeast with defects in amino acid metabolism and cell polarity

ABSTRACT Microorganisms in nature form communities through diverse interactions, such as mutualism and competition, to adapt to their ecological environments. These interactions seem to be mediated by extracellular metabolites (exometabolites), yet the chemical and biological diversity underlying these processes remain...

Ryotaro Yoshizumi, Shunichi Miura, Hiroaki Matoba et al. · 0 citations
Open access Sep 2026

Exploring the Substrate Selectivity of the Condensation Domain VibH through Engineered Adenylation Domains, Non-Native Amide Synthesis, and Substrate Recognition Analysis.

Nonribosomal peptide synthetases (NRPSs) are modular assembly-line enzymes that generate structurally diverse and biologically active natural products. Although adenylation (A) domain selectivity has been extensively characterized and engineered, the specificity of condensation (C) domains, which catalyze peptide bond...

F. Ishikawa, Hiroyuki Izuno, Shinya Nakamura et al. · 0 citations

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