Hiroyoshi Nishikawa

Mitochondrial DNA abundance is a determinant of immunogenic cell death in cancer.

Cells experiencing mitochondrial stress can undergo apoptosis or cell death that triggers innate immune activation. We examined the mechanisms determining these distinct outcomes in cancer. Abundant mitochondrial DNA (mtDNA) and high expression of the cGAS-STING pathway were features of KRAS-mutant cancers. In a pharma...