Deciphering Protein-Protein Interactions in Suspension Formulation of Neutral Protamine Hagedorn Insulin Using Hydrogen/Deuterium Exchange-Mass Spectrometry.
Recombinant insulin and insulin analogues have a range of time-action profiles, which are modulated either by incorporating mutations into the native insulin sequence or through modification of formulation compositions. Neutral protamine Hagedorn insulin suspension is an intermediate-acting insulin in which the time-ac...