Structural and Functional Analysis of GGPPS Inhibition as a Therapeutic Mechanism for Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a hematological malignancy with poor treatment options and high mortality rates. AML progression is influenced by signaling events facilitated by small GTPases anchored to cellular membranes via post-translational modification with geranylgeranyl pyrophosphate (GGPP). Herein, we show t...