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Author

Ho-Yin Chu

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Open access Sep 2026

AlphaGenome Atlas: in silico mutagenesis of the entire human genome improves prioritization and interpretation of non-coding variants

A major challenge in genomics is deciphering the functional consequences of non-coding genetic variation. Here we present AlphaGenome Atlas, a comprehensive resource that enables the joint interpretation and prioritization of variant effects across the entire human genome. Using AlphaGenome, we predicted the regulatory...

Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen et al. · 3 citations · ⚡1
Open access Sep 2026

Sequence and structural determinants of efficacious de novo chimaeric antigen receptors

This framework synthesizes generative protein design workflows to screen 1,758 newly designed protein binders targeting BCMA, CD19 and CD22 for efficacy in scalable protein-binding, T-cell activation and in vivo killing assays, and develops computational and experimental heuristics to overcome limitations.

Arthur Chow, Ho-Yin Chu, Ruo-Fan Li et al. · 5 citations

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