Hok-Sau Kwong

A recombinant heterotrimeric mini-procollagen I reveals new functional and structural roles for the α2(I) chain

Collagen I provides mechanical stability to organs and plays a critical role in several physiological processes such as wound healing and bone remodeling. Its ability to form fibrils depends on the proteolytic conversion of soluble procollagen I into mature protomers. However, the mechanistic aspects of this critical s...