Review
Open access
Jul 2026
Beyond Sequence: Posttranslational Remodeling of Antigens in Autoimmunity
Autoimmune responses are often attributed to failed tolerance to self‐proteins, yet protein expression alone cannot explain why certain antigens dominate disease, why autoreactivity emerges under stress, or why specific HLA alleles shape risk. This review presents a framework in which autoimmunity arises from posttrans...
Cynthiya Shrestha, Holly M. Weisfelder, Thanh D. Do
· Immunological Reviews · 0 citations