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Author

Hong-Bin Li

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2 papers indexed here

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Review Open access Aug 2026

Structural dynamics, pathogenic mechanisms, and therapeutic targeting of the NLRP3 inflammasome in lupus nephritis

Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome plays a central role in the pathogenesis of LN. Aberrant activation of the NLRP3 inflammasome directly promotes glomerula...

Hong-Fei Sun, Xin-Ran Xie, Ming-Ru Ma et al. · 0 citations
Review Open access Aug 2026

NLRP3 inflammasome in acute kidney injury: molecular mechanisms, post-translational regulation, and immunotherapeutic potential

This review elucidates the molecular composition of the NLRP3 inflammasome, its canonical and non-canonical activation pathways, and integrates the critical roles of post-translational modifications in regulating its activation, as well as their specific activation mechanisms across distinct subtypes of AKI.

Ming-Ru Ma, Man-Ling Zhang, Hong-Fei Sun et al. · 0 citations

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