Reconstruction of the hematopoietic system using bone marrow, thymus, and spleen organoids: Construction strategies and research advances.
Hematopoietic development and systemic homeostasis depend critically on specific three-dimensional (3D) microenvironments within the bone marrow, thymus, and spleen. Traditional two-dimensional (2D) cultures and animal models frequently fail to recapitulate human physiology due to spatial limitations and interspecies g...