Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling.
Ovarian cancer (OC) is a prevalent gynecological malignancy, with cisplatin (CDDP) serving as the cornerstone of its clinical management. However, the disease progression or recurrence attributable to CDDP resistance has become a major cause of the poor prognosis in OC. Beyond endogenous genetic or epigenetic drivers,...