Targeted phagocytosis of TNF-α by CAR macrophages restores immune homeostasis in arthritis
Rationale Dysregulated phagocytic clearance within the synovial microenvironment contributes to persistent inflammation and impairs immune homeostasis in rheumatoid arthritis (RA). Because MerTK-positive macrophages are essential for efferocytosis and inflammation resolution, but are functionally impaired in RA, this s...