In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy
ABSTRACT Limited aqueous dispersibility and potential off‐target toxicity hinder the development and clinical translation of proteolysis‐targeting chimeras (PROTACs). Herein, a bioactive self‐delivering “Split Nano‐Assembly of Photosensitizers and Targeting Chimeras” (SNAP‐TAC) theranostic platform is developed to addr...