Open access
Sep 2026
The TRAF6-Akt axis is required for efficient lytic replication of KSHV
TRAF6 is traditionally recognized as an antiviral ubiquitin E3 ligase that positively regulates the production of type I interferon and inflammatory cytokines. However, our study reveals that TRAF6 also plays a crucial role in the lytic replication of Kaposi’s sarcoma-associated herpesvirus (KSHV). Mechanistically, dur...
Zhen-Shan Liu, Qing-Yu Guo, Weili Wang et al.
· PLoS Pathogens · 0 citations