Antibody-Drug Conjugates Against Multidrug-Resistant Cancers: Biomarker-Guided Patient Selection, Payload Engineering, Linker Chemistry, and Bystander Effects.
A comprehensive analysis of the molecular structure of ADCs, the pharmacological principles underlying their potent cytotoxic activity against MDR cancer cells, the genomic and transcriptomic biomarkers that guide ADC patient selection, and the emerging resistance mechanisms that will shape the next generation of promi...