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Open access Aug 2026

Muscarinic acetylcholine receptor M2 in the anterior cingulate cortex mediates central sensitization after peripheral nerve injury

Results indicate that the activity of mAChRs M2 in ACC pyramidal neurons is necessary for GluA1-dependent synaptic strengthening and pain sensitization, and targeting this receptor may represent a viable strategy for alleviating ACC-mediated chronic pain.

Yu-Hai He, Sun-Wook Moon, Song-Qi Li et al. · 0 citations

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