Hong-Kui Zeng

Neocortical long-range inhibition promotes cortical synchrony and sleep

Sleep and wakefulness are associated with distinct cortical patterns of rhythmic activity1. During low-arousal states such as slow-wave sleep, synchronous low-frequency rhythms dominate activity across widespread cortical regions. Although inhibitory neurons are increasingly recognized as key regulators of cortical sta...

Projection-defined modules reveal mouse motor cortex architecture.

The motor cortex (MO) coordinates movement through its complex connectivity. However, despite evidence for functionally and anatomically distinct areas, organizing principles of MO lack consensus. Here, we show that the subcortical projections of mouse MO define 16 different modules. Subcortical output divergence align...

Spatiotemporal clonal architecture of the newborn mouse forebrain.